Batch Details: PT10-A2
PT-141 is a research-grade melanocortin receptor agonist derived from α-MSH analog chemistry (non-selective, MC4R-preferring). Unlike peripheral nitric-oxide–based pathways, PT-141 acts centrally, making it a useful probe for dissecting hypothalamic and mesolimbic circuits governing motivation, arousal, and energy balance.
Research Significance
Potent activation of melanocortin signaling (predominantly MC4R) in CNS models
Tool for mapping neural circuits underlying arousal, reward, and autonomic output
Distinct mechanism from vasodilatory pathways; enables comparative pharmacology
Evaluations of peptide stability, receptor selectivity, and downstream transcriptional responses
Potential Research Applications
Behavioral neuroscience paradigms (motivation, conditioning, arousal indices)
Hypothalamic regulation of energy homeostasis and autonomic tone
GPCR signaling studies (receptor bias, desensitization, cross-talk)
Structure–activity relationship (SAR) and formulation/stability investigations
Specifications
Form: Lyophilized peptide powder
Content: PT-141 (Bremelanotide)
Identity: Cyclic melanocortin peptide; MC4R-preferring agonist
Storage: Store at −20 °C; once reconstituted, use promptly under sterile lab conditions
