Batch Details: 5AM-A2
5-Amino-1MQ is a research-grade NNMT inhibitor designed to modulate cellular methylation flux and nicotinamide handling. NNMT activity has been linked to regulation of adipocyte energy balance, lipid storage, and insulin signaling; inhibiting this enzyme with 5-Amino-1MQ allows targeted investigation of these metabolic pathways in vitro and in vivo models.
Research Significance
Potent inhibition of NNMT, an enzyme associated with altered lipid accumulation and metabolic dysfunction
Tool for probing NAD⁺-dependent energy pathways and downstream sirtuin/mitochondrial signaling
Used in models evaluating fat mass, insulin sensitivity, and metabolic rate under obesogenic conditions
Supports studies of methyl donor utilization and epigenetic/metabolic cross-talk
Potential Research Applications
Obesity, lipolysis, and adipocyte differentiation studies
Insulin resistance and glucose homeostasis models
Mitochondrial efficiency, cellular energetics, and NAD⁺ salvage pathway investigations
Systems biology work on methylation balance and one-carbon metabolism
Specifications
Form: Lyophilized Powder
Content: 5-Amino-1MQ 5 mg per container
Identity: 5-Amino-1-methylquinolinium derivative; NNMT pathway modulator
Storage: Store at −20 °C, protected from light and moisture; use reconstituted/solubilized material promptly for experimental work
