Batch Details: SNAP810-A2
SNAP-8 is a research-grade neuropeptide that acts as a competitive analogue of SNAP-25, a core protein in the vesicle fusion machinery that governs neurotransmitter release. By interfering with normal SNARE complex formation, SNAP-8 has been shown in cosmetic and cellular models to decrease the release of acetylcholine, which can in turn lessen repetitive facial muscle contractions associated with expression lines.
Research Significance
Designed as an elongation of Argireline (Acetyl Hexapeptide-3 / -8), SNAP-8 adds two additional residues to create an octapeptide sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂), with the goal of improving activity versus earlier hexapeptide analogues.
Acts on the same presynaptic release pathway targeted by botulinum toxin—SNAP-25 and the SNARE complex—but through a peptide-based, non-neurotoxin mechanism that is generally positioned as noninvasive in cosmetic research literature.
Repeated topical use in cosmetic studies has been associated with measurable reductions in wrinkle depth (reported up to ~30–38% after ~28–30 days of continuous application in certain formulations), making it useful for studying neuromuscular-driven skin topography changes.
Potential Research Applications
Neuromodulation of facial expression lines via SNARE pathway interference and acetylcholine-release control
Comparative studies versus other neurotransmission-modulating peptides (e.g. Argireline) and versus botulinum toxin–type mechanisms
Formulation, delivery, and stability studies (e.g. patch, serum, or encapsulated systems) for localized cosmetic endpoints and skin surface metrics.
Specifications
Form: Lyophilized peptide powder
Content: SNAP-8 (Acetyl Octapeptide-3) 10 mg per vial
Identity: Synthetic octapeptide; sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂; designed to mimic the N-terminal domain of SNAP-25 and modulate SNARE complex formation.
Storage: Store at −20 °C, protected from light and moisture; once reconstituted, use promptly under sterile lab conditions
